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This reactive pattern forms a central litigation theme: that manufacturers waited for definitive proof of harm through patient injuries rather than exercising caution when early warning signals appeared

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[DOI] [PubMed] [Google Scholar] 64.Tonneijck L, Smits MM, Muskiet MH, Hoekstra T, Kramer MH, Danser AH, et al

Reductions in gamma-glutamyl transferase (GGT) and improvements in lipid profiles further support metabolic benefits
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Moreover, GIP has been found to boost glucose uptake by improving insulin sensitivity in adipocytes (176, 177), while tirzepatide has been demonstrated to enhance insulin sensitivity and promote glucose disposal in white adipose tissue in Glp-1r-null mice (178), further supporting a direct effect of GIP on adipose tissues