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Outcomes outside of the testing hierarchy, such as occurrence of diabetes-related morbidity (e.g., individual component of MACE or expanded composite CV outcome), change in blood pressure, and HRQoL, need to be interpreted with caution due to the possible inflated type I error

Dose optimisation may help if you are not at the maximum licensed dose and can tolerate it, but this decision must be made with your prescribing clinician, considering individual response and potential adverse effects

Additionally, emerging evidence suggests that GLP-1 receptor agonists like semaglutide may offer direct renal protection by reducing albuminuria and stabilizing kidney function, although more research is needed to fully understand these effects

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Using discount programs like GoodRx or Cost Plus Drugs can reduce expenses to under $10/month in some cases even for higher doses