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Voluntary wheel running, a well-validated proxy for exercise in rodents, provides a robust framework to evaluate GLP-1R agonist effects on physical activity, as it is intrinsically rewarding and engages neural systems regulating motivation and energy expenditure (Greenwood et al., 2011

However, Wegovy tablets still offer meaningful weight loss and are likely to appeal strongly to people who dislike needles, feel uncomfortable self-injecting, or would simply prefer the convenience of a daily tablet
