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2 The American Diabetes Association 2016 guideline details a number of second-line options for use following MET and does not give preference to one drug class over the other

Beyond the device itself, a switch usually means a few other adjustments: you might restart on the lowest dose and step up over weeks to see how you respond

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Native GLP-1 provides transient, meal-related metabolic effects lasting minutes, contributing to normal postprandial glucose regulation but offering no sustained therapeutic impact

GLP-1RA secondary to direct and mechanistic indirect effects on physiological systems have raised a need to further understand their potential in clinical practice

When combined with tirzepatide's gastrointestinal effects, this may lead to severe diarrhea, dehydration, and electrolyte imbalances