glp 1 generic drugs Comparing Ozempic, Wegovy and Other GLP-1 Compounded" GLP-1 drugs | Health

Rosenstock J, Fras JP, Rodbard HW, Tof S, Sears E, Huh R, et al

Across the 11 included studies, 91,490 participants were analysed

Harno E, Cottrell EC, Yu A et al (2013) 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors still improve metabolic phenotype in male 11beta-HSD1 knockout mice suggesting off-target mechanisms

Also, the adverse cardiovascular safety in clinical trials before 2008 was evaluated based on populations that were not necessarily at high risk of cardiovascular disease and the follow-up duration was relatively short (usually less than 12 months)

The rate of suicide attempts was over 53% lower in the GLP-1 group and over 62% lower for people with a prior history of depression or suicide attempts

Neither study showed a significant increase in amylase (7% for both studies) or lipase (28% in the LEADER trial and 31% in the SCALE trial) values after starting liraglutide compared with placebo, and the positive predictive values of amylase and lipase for pancreatitis were less than 1%