glp 1 receptor agonists incretin mimetics Mechanism of action of GLP-1 – My Endo Consult Incretins: History, Physiology, and Pharmacology

(145) demonstrated that peripherally administered liraglutide and semaglutide accessed ARH directly without crossing the blood-brain barrier

11,242,243 Long-term human studies demonstrated that chronic DPP-IV inhibition did not significantly mediate any cardiovascular (CV) benefits

The EMA stated that NAION may affect up to 1 in 10,000 people taking semaglutide and recommended that semaglutide treatment be stopped if NAION is confirmed

[DOI] [PubMed] [Google Scholar] 83

Medical Disclaimer: This information is for educational purposes only and is not medical advice

Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists