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While GIP indeed acts as an incretin in healthy individuals, researchers found an important limitation in patients with type 2 diabetes, GIP loses most of its insulinotropic efficacy (the pancreatic cells become GIP-resistant) ( [32] )

Digestive Health: Understanding that semaglutide can affect gastric emptying, we assess any existing gastrointestinal conditions, such as gastroparesis or post-surgical changes, to prevent exacerbation

One study suggests that the two most important factors in glycemic index are resistant starch and phenolic content