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Cleveland Clinic+3JAMA Network+3PMC+3 Reduced mortality: a study found weight loss surgery was associated with significantly lower all-cause mortality compared to GLP-1 therapy in patients with diabetes of less than 10 years duration as a result of greater weight loss

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While treatment strategies for AD have principally targeted individual pathological hallmarks such as amyloid and tau with limited success in modifying the disease course, to have an effective disease-modifying treatment it may be necessary to target multiple pathologies [8, 9]

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