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When treating millions of people with medications like semaglutide, even relatively rare side effects will occur in a largenumber of people Starting low and going slow is important to minimize side effects. Susan Yanovski, MD, National Institute of Diabetes and Digestive and Kidney Diseases Common Side Effects and What Helps When To Call a Doctor

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This lower retatrutide dose also means fewer GI side effects from the retatrutide itself, which is a meaningful quality-of-life improvement over the long term

62,63 In the pancreas, this pathway boosts insulin release in response to rising blood glucose, helping to keep glucose levels stable

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