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Ed.) 2014;348:g2366

All trials adopted an open-label design, except for the study of Aroda et al., which was a double-blind trial

The effect of GLP-1RA on the eGFR-related endpoint worsening kidney function was neutral in the main analysis (HR 0.86, 95% CI 0.721.02), while a statistically significant benefit was detected in the sensitivity analysis excluding ELIXA (HR 0.82, 95% CI 0.690.98) [11]

Introduction and Background GLP-1 receptor agonists (GLP-1 RAs) are a class of peptide-based drugs that mimic the human incretin hormone glucagon-like peptide-1

Diabetes Healthcare

They are potent stimulators of postprandial insulin secretion under hyperglycemic conditions and contribute to approximately 70% of the physiological postprandial insulin secretion