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SUSTAIN 6: semaglutide and cardiovascular outcomes in T2D The SUSTAIN 6 trial enrolled 3,297 patients with T2D and high cardiovascular risk (83% with established cardiovascular or kidney disease), randomizing them to semaglutide (0.5 or 1.0 mg weekly) or placebo for 104 weeks [15]

Several studies have evaluated weight regain after stopping GLP drugs

Studies show GIP receptor activation on fat tissue promotes improved lipid handling, enhanced insulin sensitivity in fat cells specifically, and changes in fat distribution patterns

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(2010) High-fat feeding stimulates endocrine, glucose-dependent insulinotropic polypeptide (GIP)-expressing cell hyperplasia in the duodenum of Wistar rats