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Increased GIP signaling induces adipose inflammation via a HIF-1alpha-dependent pathway and impairs insulin sensitivity in mice

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This can lead to deficiencies in essential vitamins and minerals, which can affect almost every system in the body, leading to weakness, fatigue, and decreased immune function

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That is more than any approved weight loss drug has produced in a comparable timeframe

And one of the reasons why this is the case is that theres something maybe a little not quite right with insulin or the GLP-1 system or both