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Tirzepatide works continuously once injected, with peak effects around 8-10 days, but weight loss depends on taking weekly doses consistently rather than relying on a single injection

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It represents a clinically significant manifestation of diabetic autonomic neuropathy and arises from a complex interplay of sustained hyperglycemia, oxidative and nitrosative stress, advanced glycation end-product accumulation, impaired insulin/IGF-1 signaling, lipid dysmetabolism, and inflammatory activation

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