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Emerging combinatorial hormone therapies for the treatment of obesity and T2DM

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GLP-1Rs are expressed primarily on GABAergic cells in the VTA Next, we showed that a behaviorally relevant dose of exendin-4 that reduced cocaine seeking 8,18 crossed the blood brain barrier, bound putative GLP-1Rs on neurons in the VTA, and induced c-Fos expression in these neurons (Suppl

Preclinical research indicates that intra-articular (IA) liraglutide attenuates synovial inflammation, decreases catabolic markers such as ADAMTS-5, and limits cartilage and bone damage across three experimental OA models, including MIA (mono-iodo-acetate), DMM (destabilization of the medial meniscus), and collagenase II-induced OA

Additionally, double KO of GPR40 and GPR120 more effectively eliminated the GIP response to the oral administration of corn oil compared to single KO of either receptor in murine models [54, 56], suggesting that both GPR40 and GPR120 are important in fat-stimulated GIP secretion [29]