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Moreover, the C-terminal serine of the peptide was replaced by cysteine via site-directed mutagenesis performed with polyethylene glycol.78 The half-life of PEG-loxenatide is approximately 1 week.123 GLP-1RAs

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Excessive fructose consumption stimulates liver lipogenesis, contributing to non-alcoholic fatty liver disease (NAFLD), a common comorbidity of T2D

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So adjunctive therapies are supposed to be therapies that help insulin with glucose-lowering. The history of adjunctive therapies in type 1 diabetes began with metformin, an oral medication approved in the U.S

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