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As of December 2024, the FDA approved tirzepatide for treatment of moderate-to-severe obstructive sleep apnea (OSA) in patients with obesity based on the results of two trials

Researchers appreciate its design because it incorporates: A 39-amino-acid sequence Carefully engineered non-natural amino acid substitutions Fatty diacid modification for prolonged stability Optimized receptor-binding characteristics Enhanced resistance to enzymatic degradation These structural characteristics are also why laboratories emphasize proper handling procedures

Medically reviewed on May 13, 2026 7 Sources Have thoughts or suggestions about this article

GLP-1 , : GLP-1 Jens Juul Holst Joel Habener 1980- , ,

Please consult your healthcare provider before making any changes to your health regimen.

10.1210/en.2013-1447 [DOI] [PubMed] [Google Scholar] Richards, P