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GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting

Williams RA, Roe LS, Rolls BJ

Originally developed for managing blood glucose levels in people with type 2 diabetes, GLP-1 receptor agonists like Ozempic have demonstrated impressive results in supporting healthy weight loss

In the brain, the two incretins are not redundant and may complement each other in regulating orexigenic and anorexigenic pathways (148)

WHO in September added GLP-1 drugs as a diabetes treatment to its list of essential medicines, but stopped short of adding them for obesity alone

GLP-1RAs also reduce food intake by modulating appetite-regulating pathways in the brain, resulting in weight loss (Koide et al., 2025) (see Figure 1)