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[1] The clinical trial data for semaglutide at the 2.4mg dose used in Wegovy did not identify menstrual irregularities or intermenstrual bleeding as a direct adverse effect of the medication

This dual-action solution works by decelerating stomach emptying and convincing the brain to feel satiated sooner, thus reducing food intake

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Collectively, the progression from exenatide to tirzepatide illustrates how extending the half-life of GLP-1R agents and incorporating additional mechanisms of action has led to substantial improvements in both glycemic control and weight loss

Together, these observations point to a mismatch between circulating GLP-1 levels and GLP-1 function

PlexusDx recommends baseline liver and kidney function tests before initiating combination therapy, with follow-up labs at 68 weeks and then annually to ensure both medications remain safe and effective