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This review outlines the rationale for their development and summarizes clinical trial data, focusing on retatrutide, the most advanced candidate

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The benefit-risk profile generally favors use in appropriate patients, particularly given the cardiovascular and metabolic benefits demonstrated in outcome trials

doi: 10.1056/NEJMoa1812389 9 MosenzonOWiviottSDCahnARozenbergAYanuvIGoodrichELet al

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