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The reduced appetite that makes Retatrutide effective also reduces thirst signals
Metformin-Induced Glucagon-Like Peptide-1 Secretion Contributes to the Actions of Metformin in Type 2 Diabetes
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While the research is promising, it is not yet robust enough to recommend GLP-1 receptor agonists as part of routine addiction treatments outside of AUD with metabolic comorbidities.
[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations
von Haehling S et al (2024) Ferric carboxymaltose and exercise capacity in heart failure with preserved ejection fraction and iron deficiency: the FAIR-HFpEF trial, (in eng)
