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Additionally, chronic treatment with GLP-1 RAs increases the abundance of anti-inflammatory microbial taxa (e.g., Bacteroidetes), which has been associated with improvements in both mood and glycemic control [94,95,99]

This dual mechanism produces more pronounced weight loss in clinical trials compared to semaglutide alone, which could mean greater estrogen reduction through adipose tissue loss

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That makes it difficult to estimate what the implant's sales could be in a GLP-1 market that some analysts expect could exceed $100 billion by the early 2030s

Rapid and extreme weight loss isnt healthy or what you should expect will happen

Implications for treatment selection As combination products become more common, the distinction between insulin and GLP-1 therapy becomes more important, not less