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doi: 10.1016/j.jacc.2008.05.060
Injectable GLP-1s, like Wegovy and Zepbound, carry an FDA boxed warning about a rare risk of thyroid cancer
Curr Med Res Opin 24: 27586, 2008
The counter-argument is that mechanistic evidence is strong, multiple lines of clinical evidence converge, and the risk profile at microdose levels is favorable
Some patients experience changes in blood glucose control when starting semaglutide, especially those on diabetes medications
Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5
