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Independently of weight loss, which may bias findings of in vivo studies, GLP-1 analogues modify human OMAT physiology favourably by increasing the insulin-sensitising cytokine adiponectin

Tirzepatide has demonstrated strong safety outcomes in clinical trials with weight loss benefits exceeding traditional GLP-1 medications

Tirzepatide has shown cardiovascular benefits in major clinical trials, but heart patients need individualized assessment before starting GLP-1 therapy

Doctors have safety concerns.

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