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By binding to GLP-1 receptors in the hypothalamus, they reduce appetite and promote satiety, leading to significant weight reduction in clinical trialswith newer agents achieving approximately 15% weight loss in obesity without diabetes (semaglutide) and up to 21% (tirzepatide), with somewhat lower reductions typically seen in patients with type 2 diabetes

Reductions in the prevalence of metabolic syndrome with tirzepatide treatment were significantly greater versus active comparators

The USFDA has approved tirzepatide under the brand name Mounjaro, which has become a revolutionary agent for the management and treatment of T2D and achieving weight loss [29,59,60]

It is believed to arise secondary to impaired left ventricular relaxation during diastole, with obesity being a significant risk factor

Ansari S, Bari A, Ullah R, Mathanmohun M, Veeraraghavan VP, Sun Z (2019) Gold nanoparticles synthesized with Smilax glabra rhizome modulates the anti-obesity parameters in high-fat diet and streptozotocin induced obese diabetes rat model

Variability of the L-Histidine Decarboxylase Gene in Allergic Rhinitis. Allergy, vol