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(PDF) Pizzagalli, D.A., Evins, A.E., Schetter, E.C., Frank, M.J., Pajtas, P.E., Santesso, D.L., Culhane, M

The need to inject the drug every week, however, can be a deterrent for the needle-phobic

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J Neurosci, 31:6587-6594

If the needle is accidentally touched or the medication is spilled, dispose of all contaminated supplies in a sharps container

The review covered GLP-1s roles in controlling islet function, appetite, inflammation, and cardiovascular pathophysiology, and made a critical mechanistic distinction: native GLP-1 acts primarily via paracrine and neural mechanisms (given its 12 minute plasma half-life), whereas GLP-1RA drugs with extended half-lives act systemically on GLP-1R populations inaccessible to the native peptide