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Some peptides are designed to help regulate appetite, while others focus on metabolic support or hormone balance

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In this review we have also highlighted and critiqued some of the key clinical and laboratory-based studies that provide data supportive of the hypothesis that metformin, independent of its anti-hyperglycemic actions, has benefits that in principle can slow cellular aging and enhance healthspan and lifespan

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Generally, their effects have been demonstrated in clinical trials in overweight and obese populations, which usually present other risk factors such as hypertension prediabetes/type 2 diabetes, dyslipidemia, and moderate or severe obstructive sleep apnea