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The estimated loss of skeletal muscle in these two major trials (10% or more during 6872 weeks of treatment) approximates the average decline in muscle mass during 20 years of agingrelated muscle loss in adults older than 30 years, estimated at 3%5% per decade (Figure 5)

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The IGF system consists of six IGF binding proteins (IGFBPs) and two growth factors (IGF-1 and IGF-2) along with their cognate insulin growth factor receptors (IGF-1R, IGF-2R) [15]

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