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Peak shape and symmetry: Sharp, symmetrical peaks indicate clean separation and pure compound

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11 This adverse effect may be related to GLP-1 R activation in the CNS, which can influence cerebrovascular tone and regional blood flow, potentially resulting in cerebral vasodilatation and headaches due to mechanical strain on pain-sensitive structures

The Phase 2 trial published in NEJM enrolled 338 adults with obesity (BMI 30) or overweight with comorbidities (BMI 27 plus at least one weight-related condition)

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Despite the exciting therapeutic potential of these multi-receptor agonists, the causal effects of activating the GLP-1R, GIPR, and GCGR pathwaysboth individually and in combinationon MASLD and its multi-organ complications are not yet clearly established [21, 23, 24]