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HFD feeding Male C57BL/6J, AMPK-KO and CKMT1-KO mice were fed a HFD (42% fat and 0.25% cholesterol, AIN93G, LabDiet), starting at 12 weeks of age and for a duration of 8 weeks for metabolic evaluations

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Patients switching from semaglutide to tirzepatide often experience renewed appetite suppression, improved energy stability, and metabolic flexibility within 46 weeks
