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[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Mehdi SF, Pusapati S, Anwar MS, et al

In a rat moderate contusive SCI model, subcutaneous administration of exenatide immediately post-injury and again at 7 days significantly improved hindlimb motor function without inducing hypoglycemia [66]

Estrogen-only patches (matrix design) usually contain medication evenly throughout and may be cut if a lower dose is needed

Through these mechanisms, GLP-1RAs promote protein clearance and reduce cellular stress that drives aggregation (Figure 1)

Replication in multisite RCTs with rigorous assessment of craving, substance use and relapse risk will be essential to determine the clinical utility of GLP1RAs in addiction medicine