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Small-molecule inhibitors such as camostat mesylate, bacitracin, soybean trypsin inhibitor, and aprotinin have also been tested for their effects on insulin metabolism

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However, several challenges remain, including the need for expanded the evidence base for a beneficial effect of semaglutide, and other GLP-1RA like medications in CKD populations without DM

These therapeutic implications may extend beyond BED to include individuals with bulimia nervosa, night eating syndrome or addictivelike eating phenotypes, who may benefit from targeted GLP1RA therapy

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