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Due to a short plasma half-life of native GLP-1, several synthesized GLP-1 receptor agonists (RAs) were developed for type 2 diabetes mellitus (DM) treatment

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Clinical trials (ten studies, 419 participants) using doses from 400 mg to 10 g over 21 days to 20 months show consistent reductions in fasting glucose, post-meal glucose, and HbA1c. In diabetic animal studies, gymnema increased proglucagon gene expression (a precursor for GLP-1) and insulin gene activity, suggesting it may help amplify endogenous GLP-1 production

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