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Description
is an animal study

These contain a rapid-acting insulin with an intermediate-acting insulin
Efficacy Data: Response rate: 79% at 3 weeks (50% reduction in MADRS) Remission rate: 75% at 4 months (phase 2, open-label extension) MADRS change: -14.08 points (CYB003 16mg) vs -8.24 points (placebo) at 3 weeks Time to response: 1-3 weeks Source Why it might interest you: Rapid onset (1-3 weeks), durable effect after single/few doses, and side effect profile lacking persistent sexual dysfunction, weight gain, or sedation make this attractive for those experiencing side effects from standard antidepressants

Curr Mol Pharmacol

doi: 10.1016/S2213-8587(18)30024-X [DOI] [PubMed] [Google Scholar] 31

Practical caution is warranted for drugs and supplements with known interactions or narrow dosing windows
