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The therapy was associated with a slight, although significant, increase in risk of atrial fibrillation, which occurred in 5.3% of patients receiving IPE compared to 3.9% in the placebo group
[DOI] [PubMed] [Google Scholar] Wang, Z

Can you drink coffee on Wegovy

Helpful ways to manage side effects include: Eat smaller, slower meals Prioritize protein and hydration Avoid heavy, greasy, or overly large meals Track symptoms and food patterns Keep regular check-ins for dose adjustments Medical supervision matters because side effects should not be ignored or managed on their own

For a broader view of how these newer agents compare, the semaglutide vs tirzepatide comparison page offers a useful starting point

The clinical picture is more nuanced - GLP-1 therapy appears most effective as part of a sustained, comprehensive approach, and most patients who discontinue the medication regain a meaningful portion of lost weight over time
