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Vagus nerve activities regulating hepatic glucose metabolism and cardiac function are both impaired in obesity, which suggests that augmentation of efferent vagus nerve activity could be beneficial in patients with hyper glycaemia, insulin resistance and cardiovascular diseases (Figure 4)
Progressive resistance exercise is the mechanical signal that tells the body to keep muscle it would otherwise shed

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Andreazza AC, Kauer-SantAnna M, Frey BN, Bond DJ, Kapczinski F, Young LT, et al

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Staying ahead of dehydration with plenty of water and electrolytes is one of the simplest ways to feel better and keep your metabolism functioning optimally