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Referral to endocrinology, cardiology, or lipid specialists may be warranted for complex cases involving multiple cardiovascular risk factors, familial hypercholesterolemia, severe hypertriglyceridemia (500 mg/dL), or inadequate response to initial therapy

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In head-to-head clinical trials, the tirzepatide group often showed greater weight reduction and better blood sugar control compared to the semaglutide group at the doses studied

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Mental disorder comorbidity and treatment utilization