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These are harder endpoints to achieve but more clinically meaningful

(2018) Mol Metab Willard et al

Natural GLP-1 lasts only a few minutes before enzymes break it down

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For women with known PCOS or other reproductive endocrine conditions, baseline and follow-up assessments of metabolic and reproductive parameters can help distinguish medication effects from underlying disease progression

Both medications require a prescription, should be used alongside a reduced calorie diet and exercise plan, and are only available as brand name medications with no generics currently on the market