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Ozempic is a glucagon-like peptide 1 receptor agonist (GLP-1) manufactured by Novo Nordisk

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The authors hypothesized a neuroprotective effect of hyperinsulinism in obese diabetic patients which could be attributed to counteracting the decrease in cell-surface gamma-aminobutyric acid receptors, reduction of glutamate, and through the regulation of the Phosphoinositide 3-Kinase (PI3K) pathway

ESSENCE is a large, randomized, double-blind, placebo-controlled study designed to enroll 1,200 adults with MASH and stage F2F3 liver fibrosis

A decreased glucose uptake in the hippocampus, parietal cortex and posterior cingulate cortex has been observed in early AD (Protas et al., 2013)