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Description

As seen in Figure 3, the fatty-acid derivatized peptides all had a higher albumin affinity than native GLP-1 ( Figure 3 While it was not possible to obtain a crystal structure of semaglutide, crystallization of the unacylated semaglutide peptide backbone in complex with the GLP-1R showed that the overall structure was identical to that of native GLP-1(7-37)

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doi: 10.1186/s13195-021-00813-8 33 Tahami MonfaredAATafazzoliAYeWChavanAZhangQ

At the histopathological level, immunohistochemical analysis of GFAP expression revealed that treatment mitigated astrogliosis in the hippocampusand brainstem apart from the MB treated group in the hippocampus