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The above study from Diabetes Obesity Metabolism said: The average change in body weight was similar in the two groups (-3.7 kg with injectable and -3.3 kg with oral at 18 months), but more new users of injectable semaglutide lost 5% body weight. According to Dr

Among those with insurance, 30% reported that affording their share of GLP-1 costs was somewhat difficult, and 25% reported that it was very difficult

Microdosing therefore changes medication exposure, not mechanism

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Some small studies, they note, have suggested that exercise can help improve VO 2 max for patients taking GLP-1 drugs, but these had poor controls and larger, well-designed studies are needed to bear that out