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Diabetes Care (2019) 42(9):172432

Background: How GLP-1s evolved from diabetes treatment to anti-obesity medications Glucagon-like peptide-1 receptor agonists (GLP-1s) have a notable history in medical treatment, beginning as therapies for type 2 diabetes and later emerging as highly effective agents for weight loss

Vomiting and diarrhea also peaked early in treatment but then declined

Case Studies and Examples To illustrate these themes, consider a few real-world examples: Novo Nordisk Catalent Integration: In early 2024 Novo Holdings announced plans to acquire Catalent (a major CDMO) for $16.5B ( [11] )

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It mitigated pyroptotic responses through modulation of the SIRT1/NOX4/ROS axis, thereby preventing gasdermin-dependent pore formation and cytokine overproduction (Yu et al., 2019)
