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In the phase 1b combination study, concomitant administration was described as well tolerated, with a safety picture consistent with the individual components

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Polycystic ovary syndrome (PCOS) , which affects up to 10% of women of reproductive age, is associated with insulin resistance and can complicate weight management, though many people with PCOS still respond well to GLP-1 therapy

The receptor for GLP-1 is the GLP-1 receptor (GLP1R), a G-protein-coupled receptor

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A maintenance approach can help make that transition feel less abrupt