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The magnitude of metabolic improvements with tirzepatide may justify higher costs if these translate into meaningful clinical outcomes
Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic beta-cells
The reduction in food intake can lead to significant weight loss
That perspective can help shift the math
Hepatology 2010;51:1584-1592
Expanding that framework, or developing alternatives that achieve similar outcomes for the commercially insured population, will require policy innovation that moves faster than the current rate of change
