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Last week, Eli Lillys orforglipron has become the first oral, non-peptide GLP-1 receptor agonist to clear a Phase 3 trial, showing strong efficacy in reducing A1C (up to 1.6%) and body weight (up to 7.9%) in people with type 2 diabetes

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have transformed the therapeutic landscape of type 2 diabetes (T2D) and obesity by offering substantial weight loss and cardiometabolic protection

Here we hypothesize that manipulating glucagon-like peptide-1 receptor (GLP-1R) activity selectively in the LH can profoundly affect food reward behavior, ultimately leading to obesity

Simultaneously, the fields of neuroscience and rare diseases are drawing significant investment as pharmaceutical companies seek the next generation of impactful specialty treatments

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