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The most serious adverse effect is metformin-associated lactic acidosis a rare but potentially fatal build-up of lactic acid in the blood

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This group typically responds well to weight and glucose control interventions, unlike the diverse participants in our real-world study

Initial doses of 0.25 mg (7.5 units) increase by 0.25 mg weekly until reaching a therapeutic dose between 2.42.5 mg (7275 units) weekly, though individual protocols vary by provider and clinical context