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"When you stop these low doses of these drugs, we don't know what's going to happen." On average, people will lose significantly less weight than they would with the maximum dose of a brand name version of the drug, McGowan agrees

Research has found that approximately 40% of the weight lost from taking semaglutide comes from lean mass, including muscle

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Adding foods rich in vitamin K, magnesium, and vitamin D such as dark green leafy vegetables, fatty fish, and nuts can also help to protect bone density during a reduction in body weight and estrogen (2, 8, 11)

They then compared them in simulated randomized trials