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In Phase 2 data published in The New England Journal of Medicine , retatrutide achieved up to about 24.2% mean body weight reduction at 48 weeks at the highest dose

doi: 10.2337/dc18-0342

Specifically, we hypothesized to find increased reward responses after administration of ghrelin and/or positive correlations with plasma ghrelin levels, and decreased reward responses after administration of GLP-1 agonists and/or negative correlations with plasma GLP-1 levels

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These structural changes allow researchers to investigate sustained activation of amylin-related signaling pathways