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Bcl-2 and Bcl-x L are also upregulated through the activation of nuclear factor B downstream of PKB (Buteau et al., 2004)

Clinical assessments were conducted every 3 months to evaluate efficacy, measured as percentage of total weight loss (%TWL), excess weight loss (%EWL), changes in BMI, and improvement in comorbidities, as well as tolerance, monitored for adverse effects including gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea) and discontinuation rates

doi: 10.1210/endo-115-6-2176

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Has constipation been an issue
