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GLP-1 agonist medications, which target the GLP-1 receptor to regulate insulin, glucagon, and appetite, offer a promising therapeutic approach to these health challenges

Some semaglutide programs include B12 in the compounded formulation specifically because of the increased risk of deficiency

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GLP-1 acts locally in the GI tract and via the vagus nerve, a key autonomic pathway that, when activated, further slows stomach emptying

Yet cardiomyocytes, the main muscle cells of the heart, and hepatocytes in the liver do not appear to express GLP-1 or GIP receptors in significant amounts

ClinicalTrials.gov Identifier: NCT04039503