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Description
Based on the CVOTs, the treatment algorithm of T2D has changed to include GLP-1RAs independent of glycaemia in patients with established CVD or high-risk (96)
Given that appetite and weight control will be key targets for an oral formulation, it is fortuitous that it is the stimulation of vagal afferents that has a direct impact on satiety effects of GLP1-RAs ( Statements Data availability statement The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author

eClinicalMedicine 58 , 101882 (2023)

Insurance coverage may be limited or denied for non-approved indications, creating significant cost barriers as these medications can exceed $1,000 monthly without coverage

A once-weekly formulation was later approved for diabetes in 2012

CagriSema has completed Phase 3 trials and Novo Nordisk is expected to file for FDA approval
